Dile Holton, Ph.D.: Characterization of Drug Binding Activity and Biopharmaceutical Stability
This webinar is focused on enthalpy screening, a new and recently published ITC technique that is showing promise for rapidly and accurately characterizing the binding enthalpy of new drugs or biotherapeutics. Rapid and accurate characterization of biopharmaceuticals is essential for the early selection of therapeutic candidates. This rapid screening technique, coupled with the fully automated Affinity ITC instrument, shortens the time required to produce the powerful thermodynamic signature for any biotherapeutic being considered for further development.
Isothermal Microcalorimetry is another critical biologic formulation analytical technique for understanding complex, high concentration formulation stability of active biopharmaceuticals. The flexible and powerful TAM IV instrument provides the high level of sensitivity required for this technique, which promises to dramatically shorten the time it takes to determine the accurate shelf-life kinetics and aggregation kinetics for protein formulations, and even new high concentration biotherapeutic formulations.
About the Speaker
Dile Holton earned his Ph.D. in Immunology and Microbiology at the Medical University of South Carolina. He has over 20 years of experience in the field of microcalorimetry, in both academic research and industrial development laboratory environments. During the course of his career he has published more than 20 research and assay development papers in the areas of cancer research and biopharmaceuticals. He has served as the worldwide microcalorimetry product manager at TA Instruments for over 8 years.